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According to the other classification, based on their morphological features, BCs are divided into three groups: mostly multipolar large BCs (LBCs), expressing PV, neuropeptide Y (NPY), and calbindin (CB) and are capable of inhibiting the neurons in neighboring columns and in upper and lower layers due to the expansive axonal arborization

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Besides this, NPs could also provide a controlled and sustained release of drugs, which maintains the therapeutic levels over extended periods and reduces side effects involved with peak-dose fluctuations